[HTML][HTML] Marked upregulation of Survivin and Aurora-B kinase is associated with disease progression in the myelodysplastic syndromes
A Yoshida, K Zokumasu, Y Wano, T Yamauchi… - …, 2012 - ncbi.nlm.nih.gov
A Yoshida, K Zokumasu, Y Wano, T Yamauchi, S Imamura, K Takagi, S Kishi, Y Urasaki…
haematologica, 2012•ncbi.nlm.nih.govBackground Myelodysplastic syndromes are a heterogeneous group of clonal hematopoietic
stem cell disorders characterized by ineffective hematopoiesis. Survivin is a member of the
inhibitor of apoptosis family and suppresses apoptosis. Survivin also functions as a subunit
of the chromosomal passenger complex for regulating mitosis with Aurora-B. Survivin and
Aurora-B play an important role in maintaining genome stability. The aim of this study was to
determine the role of Survivin and Aurora-B kinase in disease progression and prognosis of …
stem cell disorders characterized by ineffective hematopoiesis. Survivin is a member of the
inhibitor of apoptosis family and suppresses apoptosis. Survivin also functions as a subunit
of the chromosomal passenger complex for regulating mitosis with Aurora-B. Survivin and
Aurora-B play an important role in maintaining genome stability. The aim of this study was to
determine the role of Survivin and Aurora-B kinase in disease progression and prognosis of …
Abstract
Background
Myelodysplastic syndromes are a heterogeneous group of clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis. Survivin is a member of the inhibitor of apoptosis family and suppresses apoptosis. Survivin also functions as a subunit of the chromosomal passenger complex for regulating mitosis with Aurora-B. Survivin and Aurora-B play an important role in maintaining genome stability. The aim of this study was to determine the role of Survivin and Aurora-B kinase in disease progression and prognosis of myelodysplastic syndromes.
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