Aging is a natural process that determined by a functional decline in cells and tissues as
organisms are growing old, resulting in an increase at risk of disease and death. To this end,
many efforts have been made to control aging and increase lifespan and healthspan. These
efforts have led to the discovery of several anti-aging drugs and compounds such as
rapamycin and metformin. Recently, alpha-ketoglutarate (AKG) has been introduced as a
potential anti-aging metabolite that can control several functions in organisms, thereby …