All the “RAGE” in lung disease: The receptor for advanced glycation endproducts (RAGE) is a major mediator of pulmonary inflammatory responses
EA Oczypok, TN Perkins, TD Oury - Paediatric respiratory reviews, 2017 - Elsevier
The receptor for advanced glycation endproducts (RAGE) is a pro-inflammatory pattern
recognition receptor (PRR) that has been implicated in the pathogenesis of numerous
inflammatory diseases. It was discovered in 1992 on endothelial cells and was named for its
ability to bind advanced glycation endproducts and promote vascular inflammation in the
vessels of patients with diabetes. Further studies revealed that RAGE is most highly
expressed in lung tissue and spurred numerous explorations into RAGE's role in the lung …
recognition receptor (PRR) that has been implicated in the pathogenesis of numerous
inflammatory diseases. It was discovered in 1992 on endothelial cells and was named for its
ability to bind advanced glycation endproducts and promote vascular inflammation in the
vessels of patients with diabetes. Further studies revealed that RAGE is most highly
expressed in lung tissue and spurred numerous explorations into RAGE's role in the lung …