Cellular Recognition of Mycobacterium tuberculosis ESAT-6 and KatG Peptides in Systemic Sarcoidosis
WP Drake, MS Dhason, M Nadaf… - Infection and …, 2007 - Am Soc Microbiol
WP Drake, MS Dhason, M Nadaf, BE Shepherd, S Vadivelu, R Hajizadeh, LS Newman…
Infection and immunity, 2007•Am Soc MicrobiolSarcoidosis is an enigmatic disease with a pathology similar to that of tuberculosis. We
detected Th-1 immune responses to Mycobacterium tuberculosis ESAT-6 and KatG peptides
from peripheral blood mononuclear cells from 15/26 sarcoidosis, 1/24 purified-protein-
derivative-negative (PPD−)(P< 0.0001, Fisher's exact test), and 7/8 PPD-positive (PPD+)
subjects (P= 0.21). This finding provides immunologic links between mycobacteria and
systemic sarcoidosis.
detected Th-1 immune responses to Mycobacterium tuberculosis ESAT-6 and KatG peptides
from peripheral blood mononuclear cells from 15/26 sarcoidosis, 1/24 purified-protein-
derivative-negative (PPD−)(P< 0.0001, Fisher's exact test), and 7/8 PPD-positive (PPD+)
subjects (P= 0.21). This finding provides immunologic links between mycobacteria and
systemic sarcoidosis.
Abstract
Sarcoidosis is an enigmatic disease with a pathology similar to that of tuberculosis. We detected Th-1 immune responses to Mycobacterium tuberculosis ESAT-6 and KatG peptides from peripheral blood mononuclear cells from 15/26 sarcoidosis, 1/24 purified-protein-derivative-negative (PPD−) (P < 0.0001, Fisher's exact test), and 7/8 PPD-positive (PPD+) subjects (P = 0.21). This finding provides immunologic links between mycobacteria and systemic sarcoidosis.
American Society for Microbiology