[HTML][HTML] H3K27 demethylases, at long last
T Swigut, J Wysocka - Cell, 2007 - cell.com
T Swigut, J Wysocka
Cell, 2007•cell.comMethylation of lysine 27 on histone H3 (H3K27me) by the Polycomb complex (PRC2)
proteins is associated with gene silencing in many developmental processes. A cluster of
recent papers (Agger et al., 2007; De Santa et al., 2007; Lan et al., 2007; Lee et al., 2007)
identify the JmjC-domain proteins UTX and JMJD3 as H3K27-specific demethylases that
remove this methyl mark, enabling the activation of genes involved in animal body
patterning and the inflammatory response.
proteins is associated with gene silencing in many developmental processes. A cluster of
recent papers (Agger et al., 2007; De Santa et al., 2007; Lan et al., 2007; Lee et al., 2007)
identify the JmjC-domain proteins UTX and JMJD3 as H3K27-specific demethylases that
remove this methyl mark, enabling the activation of genes involved in animal body
patterning and the inflammatory response.
Methylation of lysine 27 on histone H3 (H3K27me) by the Polycomb complex (PRC2) proteins is associated with gene silencing in many developmental processes. A cluster of recent papers (Agger et al., 2007; De Santa et al., 2007; Lan et al., 2007; Lee et al., 2007) identify the JmjC-domain proteins UTX and JMJD3 as H3K27-specific demethylases that remove this methyl mark, enabling the activation of genes involved in animal body patterning and the inflammatory response.
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