[HTML][HTML] Transcription factor PU. 1 controls transcription start site positioning and alternative TLR4 promoter usage
M Lichtinger, R Ingram, M Hornef, C Bonifer… - Journal of Biological …, 2007 - ASBMB
Human and mouse show markedly different sensitivities toward bacterial endotoxins, and
recent evidence suggests that a species-specific regulation of the lipopolysaccharide
receptor Toll-like receptor 4 (Tlr4) may contribute to this phenomenon. To gain further insight
into mechanisms of Tlr4 regulation, we conducted a detailed in vivo and in vitro study of the
murine Tlr4 gene, including analysis of transcription start site location, transcription factor
occupancy, and activities of its proximal regulatory sequences. Our analyses identified a PU …
recent evidence suggests that a species-specific regulation of the lipopolysaccharide
receptor Toll-like receptor 4 (Tlr4) may contribute to this phenomenon. To gain further insight
into mechanisms of Tlr4 regulation, we conducted a detailed in vivo and in vitro study of the
murine Tlr4 gene, including analysis of transcription start site location, transcription factor
occupancy, and activities of its proximal regulatory sequences. Our analyses identified a PU …