Chronic morphine administration differentially modulates viral reservoirs in SIVmac251 infected rhesus macaque model
A Acharya, OA Olwenyi, M Thurman, K Pandey… - bioRxiv, 2020 - biorxiv.org
HIV persists in cellular reservoirs despite effective anti-retroviral therapy with rebound of
viremia upon therapy interruption. Opioids modulate the immune system and suppress
antiviral gene responses, which significantly impact people living with HIV (PLWH).
However, the effects of opioids on viral reservoir remains elusive. Herein, we describe a
morphine dependent SIVmac251 infected Rhesus macaque (RM) model to study the impact
of opioids on HIV reservoirs. RMs were ramped up with morphine (n= 10) or saline (n= 9) for …
viremia upon therapy interruption. Opioids modulate the immune system and suppress
antiviral gene responses, which significantly impact people living with HIV (PLWH).
However, the effects of opioids on viral reservoir remains elusive. Herein, we describe a
morphine dependent SIVmac251 infected Rhesus macaque (RM) model to study the impact
of opioids on HIV reservoirs. RMs were ramped up with morphine (n= 10) or saline (n= 9) for …
Chronic morphine administration differentially modulates viral reservoirs in a simian immunodeficiency virus SIVmac251-infected rhesus macaque model
A Acharya, OA Olwenyi, M Thurman, K Pandey… - Journal of …, 2021 - Am Soc Microbiol
Human immunodeficiency virus (HIV) persists in cellular reservoirs despite effective
combined antiretroviral therapy (cART), and there is viremia flare-up upon therapy
interruption. Opioids modulate the immune system and suppress antiviral gene responses,
which significantly impact people living with HIV (PLWH). However, the effect of opioids on
viral reservoir dynamics remains elusive. Here, we developed a morphine-dependent
simian immunodeficiency virus SIVmac251-infected rhesus macaque (RM) model to study …
combined antiretroviral therapy (cART), and there is viremia flare-up upon therapy
interruption. Opioids modulate the immune system and suppress antiviral gene responses,
which significantly impact people living with HIV (PLWH). However, the effect of opioids on
viral reservoir dynamics remains elusive. Here, we developed a morphine-dependent
simian immunodeficiency virus SIVmac251-infected rhesus macaque (RM) model to study …
