Bone-targeting systems to systemically deliver therapeutics to bone fractures for accelerated healing
JJ Nielsen, SA Low - Current osteoporosis reports, 2020 - Springer
Current osteoporosis reports, 2020•Springer
Abstract Purpose of Review Compared with the current standard of implanting bone
anabolics for fracture repair, bone fracture-targeted anabolics would be more effective, less
invasive, and less toxic and would allow for control over what phase of fracture healing is
being affected. We therefore sought to identify the optimal bone-targeting molecule to allow
for systemic administration of therapeutics to bone fractures. Recent Findings We found that
many bone-targeting molecules exist, but most have been developed for the treatment of …
anabolics for fracture repair, bone fracture-targeted anabolics would be more effective, less
invasive, and less toxic and would allow for control over what phase of fracture healing is
being affected. We therefore sought to identify the optimal bone-targeting molecule to allow
for systemic administration of therapeutics to bone fractures. Recent Findings We found that
many bone-targeting molecules exist, but most have been developed for the treatment of …
Purpose of Review
Compared with the current standard of implanting bone anabolics for fracture repair, bone fracture-targeted anabolics would be more effective, less invasive, and less toxic and would allow for control over what phase of fracture healing is being affected. We therefore sought to identify the optimal bone-targeting molecule to allow for systemic administration of therapeutics to bone fractures.
Recent Findings
We found that many bone-targeting molecules exist, but most have been developed for the treatment of bone cancers, osteomyelitis, or osteoporosis. There are a few examples of bone-targeting ligands that have been developed for bone fractures that are selective for the bone fracture over the body and skeleton.
Summary
Acidic oligopeptides have the ideal half-life, toxicity profile, and selectivity for a bone fracture-targeting ligand and are the most developed and promising of these bone fracture-targeting ligands. However, many other promising ligands have been developed that could be used for bone fractures.
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