The nutrient and energy sensor sirt1 regulates the hypothalamic-pituitary-adrenal (HPA) axis by altering the production of the prohormone convertase 2 (PC2) …
Understanding the role of hypothalamic neuropeptides and hormones in energy balance is
paramount in the search for approaches to mitigate the obese state. Increased hypothalamic-
pituitary-adrenal axis activity leads to increased levels of glucocorticoids (GC) that are
known to regulate body weight. The axis initiates the production and release of corticotropin-
releasing hormone (CRH) from the paraventricular nucleus (PVN) of the hypothalamus.
Levels of active CRH peptide are dependent on the processing of its precursor pro-CRH by …
paramount in the search for approaches to mitigate the obese state. Increased hypothalamic-
pituitary-adrenal axis activity leads to increased levels of glucocorticoids (GC) that are
known to regulate body weight. The axis initiates the production and release of corticotropin-
releasing hormone (CRH) from the paraventricular nucleus (PVN) of the hypothalamus.
Levels of active CRH peptide are dependent on the processing of its precursor pro-CRH by …
