[HTML][HTML] Sequestosome 1/p62 enhances chronic skin inflammation
S Sukseree, L Bakiri, M Palomo-Irigoyen… - Journal of Allergy and …, 2021 - Elsevier
Background The molecular control of inflammation and epidermal thickening in skin lesions
of patients with atopic dermatitis (AD) is not known. Sequestosome 1/p62 is a multifunctional
adapter protein implicated in the control of key regulators of cellular homeostasis, such as
proinflammatory and mechanistic target of rapamycin signaling. Objective We sought to
determine whether p62 plays a role in the cutaneous and systemic manifestations of an AD-
like mouse model. Methods AD-like skin lesions were induced by deletion of JunB/AP-1 …
of patients with atopic dermatitis (AD) is not known. Sequestosome 1/p62 is a multifunctional
adapter protein implicated in the control of key regulators of cellular homeostasis, such as
proinflammatory and mechanistic target of rapamycin signaling. Objective We sought to
determine whether p62 plays a role in the cutaneous and systemic manifestations of an AD-
like mouse model. Methods AD-like skin lesions were induced by deletion of JunB/AP-1 …