[HTML][HTML] Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity
SP Saunders, T Moran, A Floudas, F Wurlod… - Journal of Allergy and …, 2016 - Elsevier
Background Atopic dermatitis (AD) is an inflammatory skin condition that can occur in early
life, predisposing to asthma development in a phenomenon known as the atopic march.
Although genetic and environmental factors are known to contribute to AD and asthma, the
mechanisms underlying the atopic march remain poorly understood. Filaggrin loss-of-
function mutations are a major genetic predisposer for the development of AD and
progression to AD-associated asthma. Objective We sought to experimentally address …
life, predisposing to asthma development in a phenomenon known as the atopic march.
Although genetic and environmental factors are known to contribute to AD and asthma, the
mechanisms underlying the atopic march remain poorly understood. Filaggrin loss-of-
function mutations are a major genetic predisposer for the development of AD and
progression to AD-associated asthma. Objective We sought to experimentally address …