Basis for the barrier abnormality in atopic dermatitis: outside-inside-outside pathogenic mechanisms
PM Elias, Y Hatano, ML Williams - Journal of Allergy and Clinical …, 2008 - Elsevier
Until quite recently, the pathogenesis of atopic dermatitis (AD) has been attributed to primary
abnormalities of the immune system. Intensive study revealed the key roles played by
TH1/TH2 cell dysregulation, IgE production, mast cell hyperactivity, and dendritic cell
signaling in the evolution of the chronic, pruritic, inflammatory dermatosis that characterizes
AD. Accordingly, current therapy has been largely directed toward ameliorating TH2-
mediated inflammation and pruritus. In this review we will assess emerging evidence that …
abnormalities of the immune system. Intensive study revealed the key roles played by
TH1/TH2 cell dysregulation, IgE production, mast cell hyperactivity, and dendritic cell
signaling in the evolution of the chronic, pruritic, inflammatory dermatosis that characterizes
AD. Accordingly, current therapy has been largely directed toward ameliorating TH2-
mediated inflammation and pruritus. In this review we will assess emerging evidence that …