[HTML][HTML] Autophagy enhances intestinal epithelial tight junction barrier function by targeting claudin-2 protein degradation
PK Nighot, CAA Hu, TY Ma - Journal of Biological Chemistry, 2015 - ASBMB
Autophagy is an intracellular degradation pathway and is considered to be an essential cell
survival mechanism. Defects in autophagy are implicated in many pathological processes,
including inflammatory bowel disease. Among the innate defense mechanisms of intestinal
mucosa, a defective tight junction (TJ) barrier has been postulated as a key pathogenic
factor in the causation and progression of inflammatory bowel disease by allowing
increased antigenic permeation. The cross-talk between autophagy and the TJ barrier has …
survival mechanism. Defects in autophagy are implicated in many pathological processes,
including inflammatory bowel disease. Among the innate defense mechanisms of intestinal
mucosa, a defective tight junction (TJ) barrier has been postulated as a key pathogenic
factor in the causation and progression of inflammatory bowel disease by allowing
increased antigenic permeation. The cross-talk between autophagy and the TJ barrier has …