Mechanism of HBD-3 deficiency in atopic dermatitis
MD Howell, M Boguniewicz, S Pastore, N Novak… - Clinical …, 2006 - Elsevier
Extrinsic atopic dermatitis (EAD) and intrinsic atopic dermatitis (IAD) patients suffer from
recurrent bacterial and viral infections. In this study, we demonstrate significantly decreased
expression of human beta defensin (HBD)-3, a potent antimicrobial peptide (AMP), in
lesional skin of both IAD (p< 0.01) and EAD patients (p< 0.01), as compared to psoriasis
patients. Using primary keratinocytes from EAD and IAD patients, we determined that the
deficiency in HBD-3 expression is an acquired rather than a constitutive defect. Furthermore …
recurrent bacterial and viral infections. In this study, we demonstrate significantly decreased
expression of human beta defensin (HBD)-3, a potent antimicrobial peptide (AMP), in
lesional skin of both IAD (p< 0.01) and EAD patients (p< 0.01), as compared to psoriasis
patients. Using primary keratinocytes from EAD and IAD patients, we determined that the
deficiency in HBD-3 expression is an acquired rather than a constitutive defect. Furthermore …