Atopic dermatitis (AD) is the most common inflammatory skin disease in the industrialized
world and has multiple causes. Over the past decade, data from both experimental models
and patients have highlighted the primary pathogenic role of skin barrier deficiency in
patients with AD. Increased access of environmental agents into the skin results in chronic
inflammation and contributes to the systemic “atopic (allergic) march.” In addition, persistent
skin inflammation further attenuates skin barrier function, resulting in a positive feedback …