[HTML][HTML] Kdm4b histone demethylase is a DNA damage response protein and confers a survival advantage following γ-irradiation
LC Young, DW McDonald, MJ Hendzel - Journal of Biological Chemistry, 2013 - ASBMB
DNA damage evokes a complex and highly coordinated DNA damage response (DDR) that
is integral to the suppression of genomic instability. Double-strand breaks (DSBs) are
considered the most deleterious form damage. Evidence suggests that trimethylation of
histone H3 lysine 9 (H3K9me3) presents a barrier to DSB repair. Also, global levels of
histone methylation are clinically predictive for several tumor types. Therefore,
demethylation of H3K9 may be an important step in the repair of DSBs. The KDM4 subfamily …
is integral to the suppression of genomic instability. Double-strand breaks (DSBs) are
considered the most deleterious form damage. Evidence suggests that trimethylation of
histone H3 lysine 9 (H3K9me3) presents a barrier to DSB repair. Also, global levels of
histone methylation are clinically predictive for several tumor types. Therefore,
demethylation of H3K9 may be an important step in the repair of DSBs. The KDM4 subfamily …
