Large T and small T antigens of Merkel cell polyomavirus
Highlights•Merkel cell polyomavirus (MCV) is a newly discovered human tumor virus that
causes Merkel cell carcinoma (MCC).•MCV is clonally integrated in MCC tumor cells.•Large
T antigens carry signature C-terminal truncations in MCC.•MCV-associated tumorigenesis is
characterized by the expression of LT and sT antigens.•Functional domains and motifs of LT
and sT mediate MCV tumorigenesis.Merkel cell polyomavirus (MCV) is the etiological agent
of Merkel cell carcinoma (MCC), a rare and highly lethal human skin cancer. A natural …
causes Merkel cell carcinoma (MCC).•MCV is clonally integrated in MCC tumor cells.•Large
T antigens carry signature C-terminal truncations in MCC.•MCV-associated tumorigenesis is
characterized by the expression of LT and sT antigens.•Functional domains and motifs of LT
and sT mediate MCV tumorigenesis.Merkel cell polyomavirus (MCV) is the etiological agent
of Merkel cell carcinoma (MCC), a rare and highly lethal human skin cancer. A natural …
