Blockade of platelet-activating factor receptor attenuates abnormal behaviors induced by phencyclidine in mice through down-regulation of NF-κB
TV Tran, SJ Park, EJ Shin, HQ Tran, JH Jeong… - Brain Research …, 2018 - Elsevier
Accumulating evidence suggests that neuroinflammation is one of the important etiologic
factors of abusive and neuropsychiatric disorders. Platelet-activating factor (PAF) is potent
proinflammatory lipid mediat1or and plays a pivotal role in neuroinflammatory disorders
through the specific PAF receptor (PAF-R). Phencyclidine (PCP) induces a psychotomimetic
state that closely resembles schizophrenia. Here, we investigated the role of PAF-R in the
abnormal behaviors induced by PCP in mice. Repeated treatment with PCP resulted in a …
factors of abusive and neuropsychiatric disorders. Platelet-activating factor (PAF) is potent
proinflammatory lipid mediat1or and plays a pivotal role in neuroinflammatory disorders
through the specific PAF receptor (PAF-R). Phencyclidine (PCP) induces a psychotomimetic
state that closely resembles schizophrenia. Here, we investigated the role of PAF-R in the
abnormal behaviors induced by PCP in mice. Repeated treatment with PCP resulted in a …
