Histone deacetylases and cancer
MA Glozak, E Seto - Oncogene, 2007 - nature.com
MA Glozak, E Seto
Oncogene, 2007•nature.comHistone deacetylases (HDACs) regulate the expression and activity of numerous proteins
involved in both cancer initiation and cancer progression. By removal of acetyl groups from
histones, HDACs create a non-permissive chromatin conformation that prevents the
transcription of genes that encode proteins involved in tumorigenesis. In addition to
histones, HDACs bind to and deacetylate a variety of other protein targets including
transcription factors and other abundant cellular proteins implicated in control of cell growth …
involved in both cancer initiation and cancer progression. By removal of acetyl groups from
histones, HDACs create a non-permissive chromatin conformation that prevents the
transcription of genes that encode proteins involved in tumorigenesis. In addition to
histones, HDACs bind to and deacetylate a variety of other protein targets including
transcription factors and other abundant cellular proteins implicated in control of cell growth …
Abstract
Histone deacetylases (HDACs) regulate the expression and activity of numerous proteins involved in both cancer initiation and cancer progression. By removal of acetyl groups from histones, HDACs create a non-permissive chromatin conformation that prevents the transcription of genes that encode proteins involved in tumorigenesis. In addition to histones, HDACs bind to and deacetylate a variety of other protein targets including transcription factors and other abundant cellular proteins implicated in control of cell growth, differentiation and apoptosis. This review provides a comprehensive examination of the transcriptional and post-translational mechanisms by which HDACs alter the expression and function of cancer-associated proteins and examines the general impact of HDAC activity in cancer.
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