[HTML][HTML] Biliary epithelium and liver B cells exposed to bacteria activate intrahepatic MAIT cells through MR1
HC Jeffery, B Van Wilgenburg, A Kurioka, K Parekh… - Journal of …, 2016 - Elsevier
Background & Aims Mucosal-Associated Invariant T (MAIT) cells are innate-like T cells
characterised by the invariant TCR-chain, Vα7. 2-Jα33, and are restricted by MR1, which
presents bacterial vitamin B metabolites. They are important for antibacterial immunity at
mucosal sites; however, detailed characteristics of liver-infiltrating MAIT (LI-MAIT) and their
role in biliary immune surveillance remain unexplored. Methods The phenotype and
intrahepatic localisation of human LI-MAIT cells was examined in diseased and normal …
characterised by the invariant TCR-chain, Vα7. 2-Jα33, and are restricted by MR1, which
presents bacterial vitamin B metabolites. They are important for antibacterial immunity at
mucosal sites; however, detailed characteristics of liver-infiltrating MAIT (LI-MAIT) and their
role in biliary immune surveillance remain unexplored. Methods The phenotype and
intrahepatic localisation of human LI-MAIT cells was examined in diseased and normal …