Liver fibrosis induced by hepatic overexpression of PDGF-B in transgenic mice
P Czochra, B Klopcic, E Meyer, J Herkel… - Journal of …, 2006 - Elsevier
BACKGROUND/AIMS: In hepatic fibrogenesis, stellate cells are activated leading to
production and deposition of extracellular matrix. To clarify the role of PDGF-B in liver
fibrogenesis, we overexpressed PDGF-B in the liver of transgenic mice. METHODS:
Transgenic mice for the conditional overexpression of PDGF-B in the liver under control of
an albumin promoter were generated utilising the Cre/loxP system. Constitutive PDGF-B
expression was achieved after breeding with mice expressing Cre-recombinase under actin …
production and deposition of extracellular matrix. To clarify the role of PDGF-B in liver
fibrogenesis, we overexpressed PDGF-B in the liver of transgenic mice. METHODS:
Transgenic mice for the conditional overexpression of PDGF-B in the liver under control of
an albumin promoter were generated utilising the Cre/loxP system. Constitutive PDGF-B
expression was achieved after breeding with mice expressing Cre-recombinase under actin …