ApoE and the role of very low density lipoproteins in adipose tissue inflammation
J Wang, X Dai Perrard, JL Perrard, A Mukherjee… - Atherosclerosis, 2012 - Elsevier
OBJECTIVE: To identify the role of triglyceride-rich lipoproteins (TGRLs) and apoE, a major
apolipoprotein in TGRLs, in adipose tissue inflammation with high-fat diet (HFD)-induced
obesity. METHODS: Male apoE−/− and C57BL/6J wild-type (WT) mice fed HFD for 12 weeks
were assessed for metabolic and inflammatory parameters. ApoE−/− and WT mice were
orally gavaged with [3H] palmitic acid to examine the role of apoE in fat delivery to adipose
tissue. VLDL from obese apoE−/− mice were intravenously injected into lean WT or apoE …
apolipoprotein in TGRLs, in adipose tissue inflammation with high-fat diet (HFD)-induced
obesity. METHODS: Male apoE−/− and C57BL/6J wild-type (WT) mice fed HFD for 12 weeks
were assessed for metabolic and inflammatory parameters. ApoE−/− and WT mice were
orally gavaged with [3H] palmitic acid to examine the role of apoE in fat delivery to adipose
tissue. VLDL from obese apoE−/− mice were intravenously injected into lean WT or apoE …