Four and a half LIM protein 1 (FHL1/SLIM1) is highly expressed in skeletal and cardiac
muscle; however, the function of FHL1 remains unknown. Yeast two-hybrid screening
identified slow type skeletal myosin-binding protein C as an FHL1 binding partner. Myosin-
binding protein C is the major myosin-associated protein in striated muscle that enhances
the lateral association and stabilization of myosin thick filaments and regulates actomyosin
interactions. The interaction between FHL1 and myosin-binding protein C was confirmed …