[HTML][HTML] Mucosal-associated invariant T (MAIT) cells: an evolutionarily conserved T cell subset
E Treiner, L Duban, IC Moura, T Hansen, S Gilfillan… - Microbes and …, 2005 - Elsevier
Besides mainstream TCRαβ T cells harboring a very diverse repertoire, two subsets display
an evolutionarily conserved invariant repertoire. This striking conservation indicates
important and unique functions. CD1d-restricted NK-T cells expressing an invariant Vα14
TCRα chain have been implicated in microbial and tumor responses as well as in auto-
immunity. In this review, we describe the other subset, which bears the canonical hVα7.
2/mVα19-Jα33 TCRα chain paired with a restricted set of Vβ segments. These invariant T …
an evolutionarily conserved invariant repertoire. This striking conservation indicates
important and unique functions. CD1d-restricted NK-T cells expressing an invariant Vα14
TCRα chain have been implicated in microbial and tumor responses as well as in auto-
immunity. In this review, we describe the other subset, which bears the canonical hVα7.
2/mVα19-Jα33 TCRα chain paired with a restricted set of Vβ segments. These invariant T …
