Proteinase 3 mRNA expression is induced in monocytes but not in neutrophils of patients with cystic fibrosis
J Just, C Moog-Lutz, A Houzel-Charavel… - FEBS …, 1999 - Wiley Online Library
J Just, C Moog-Lutz, A Houzel-Charavel, S Canteloup, A Grimfeld, V Witko-Sarsat, YE Cayre
FEBS letters, 1999•Wiley Online LibraryProteinase 3 (PR3), a serine proteinase which can degrade lung tissue, is present in the
cystic fibrosis (CF) sputum. In the present study, PR3 protein and mRNA expression was
determined in circulating neutrophils and monocytes. CF neutrophils contained similar PR3
concentrations as healthy controls and poorly expressed PR3 mRNA. In contrast, CF
monocytes showed significantly higher PR3 concentrations than controls, together with an
upregulation of PR3 mRNA expression especially during pulmonary exacerbation …
cystic fibrosis (CF) sputum. In the present study, PR3 protein and mRNA expression was
determined in circulating neutrophils and monocytes. CF neutrophils contained similar PR3
concentrations as healthy controls and poorly expressed PR3 mRNA. In contrast, CF
monocytes showed significantly higher PR3 concentrations than controls, together with an
upregulation of PR3 mRNA expression especially during pulmonary exacerbation …
Proteinase 3 (PR3), a serine proteinase which can degrade lung tissue, is present in the cystic fibrosis (CF) sputum. In the present study, PR3 protein and mRNA expression was determined in circulating neutrophils and monocytes. CF neutrophils contained similar PR3 concentrations as healthy controls and poorly expressed PR3 mRNA. In contrast, CF monocytes showed significantly higher PR3 concentrations than controls, together with an upregulation of PR3 mRNA expression especially during pulmonary exacerbation. Interestingly, antibiotic treatment fully abrogated PR3 mRNA expression and decreased PR3 protein in monocytes. Our findings highlight a potential role of monocyte‐derived PR3 in CF‐associated airway inflammation.
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