Expansion of circulating NKG2D+ effector memory T-cells and expression of NKG2D-ligand MIC in granulomaous lesions in Wegener's granulomatosis
D Capraru, A Müller, E Csernok, WL Gross… - Clinical …, 2008 - Elsevier
Expansion of circulating CD28− T-cells reminiscent of effector memory T-cells (TEM) has
been reported in Wegener's granulomatosis (WG) recently. To investigate the role of TEM in
WG, we analyzed the expression of the activating NK-receptor NKG2D and its ligand MIC on
circulating TEM and in granulomatous lesions, respectively. NKG2D was anomalously
expressed and preferentially detected on circulating CD4+ CD28-TEM in WG. Compared to
healthy controls, TEM display a more activated phenotype potentially favoring unbalanced …
been reported in Wegener's granulomatosis (WG) recently. To investigate the role of TEM in
WG, we analyzed the expression of the activating NK-receptor NKG2D and its ligand MIC on
circulating TEM and in granulomatous lesions, respectively. NKG2D was anomalously
expressed and preferentially detected on circulating CD4+ CD28-TEM in WG. Compared to
healthy controls, TEM display a more activated phenotype potentially favoring unbalanced …