[PDF][PDF] Anti-microinflammatory lipid signals generated from dietary N-3 fatty acids via cyclooxygenase-2 and transcellular processing: a novel mechanism for NSAID …
Aspirin therapy inhibits mmmmSmSS biosynthesis; yet via acetylation of cyclooxygenase 2
(COX-2) it leads to bioactive lipoxins epimeric at carbon 15 (15-epi-LX, also termed aspirin-
triggered lipoxin or ATL). Here, we review our findings indicating that inflammatory exudates
from mice treated with co-3 PUFA and aspirin 浏器 generate a novel array of bioactive lipid
signals. Also, human endothelial cells, both HUVEC and microvascular, with upregulated
COX-2 and treated with ASA converted C20: 5 co-3 to 18R-hydroxyeicosapentaenoic acid …
(COX-2) it leads to bioactive lipoxins epimeric at carbon 15 (15-epi-LX, also termed aspirin-
triggered lipoxin or ATL). Here, we review our findings indicating that inflammatory exudates
from mice treated with co-3 PUFA and aspirin 浏器 generate a novel array of bioactive lipid
signals. Also, human endothelial cells, both HUVEC and microvascular, with upregulated
COX-2 and treated with ASA converted C20: 5 co-3 to 18R-hydroxyeicosapentaenoic acid …