The multivalent PDZ domain-containing protein PDZK1 regulates transport activity of renal urate-anion exchanger URAT1 via its C terminus
N Anzai, H Miyazaki, R Noshiro, S Khamdang… - Journal of Biological …, 2004 - ASBMB
The urate-anion exchanger URAT1 is a member of the organic anion transporter (OAT)
family that regulates blood urate level in humans and is targeted by uricosuric and
antiuricosuric agents (Enomoto, A., Kimura, H., Chairoungdua, A., Shigeta, Y., Jutabha, P.,
Cha, SH, Hosoyamada, M., Takeda, M., Sekine, T., Igarashi, T., Matsuo, H., Kikuchi, Y., Oda,
T., Ichida, K., Hosoya, T., Shimotaka, K., Niwa, T., Kanai, Y., and Endou, H.(2002) Nature
417, 447–452). URAT1 is expressed only in the kidney, where it is thought to participate in …
family that regulates blood urate level in humans and is targeted by uricosuric and
antiuricosuric agents (Enomoto, A., Kimura, H., Chairoungdua, A., Shigeta, Y., Jutabha, P.,
Cha, SH, Hosoyamada, M., Takeda, M., Sekine, T., Igarashi, T., Matsuo, H., Kikuchi, Y., Oda,
T., Ichida, K., Hosoya, T., Shimotaka, K., Niwa, T., Kanai, Y., and Endou, H.(2002) Nature
417, 447–452). URAT1 is expressed only in the kidney, where it is thought to participate in …
