Although hyperuricemia has long been associated with renal disease, uric acid has not
been considered as a true mediator of progression of renal disease. The observation that
hyperuricemia commonly is associated with other risk factors of cardiovascular and renal
disease, especially hypertension, has made it difficult to dissect the effect of uric acid itself.
However, recent epidemiologic evidence suggests a significant and independent
association between the level of serum uric acid and renal disease progression with …