Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial
DI Feig, B Soletsky, RJ Johnson - Jama, 2008 - jamanetwork.com
Context Hyperuricemia is a predictor for the development of hypertension and is commonly
present in new-onset essential hypertension. Experimentally increasing uric acid levels
using a uricase inhibitor causes systemic hypertension in animal models. Objective To
determine whether lowering uric acid lowers blood pressure (BP) in hyperuricemic
adolescents with newly diagnosed hypertension. Design, Setting, and Patients Randomized,
double-blind, placebo-controlled, crossover trial (September 2004-March 2007) involving 30 …
present in new-onset essential hypertension. Experimentally increasing uric acid levels
using a uricase inhibitor causes systemic hypertension in animal models. Objective To
determine whether lowering uric acid lowers blood pressure (BP) in hyperuricemic
adolescents with newly diagnosed hypertension. Design, Setting, and Patients Randomized,
double-blind, placebo-controlled, crossover trial (September 2004-March 2007) involving 30 …
