Effects of stress on methyltransferase synthesis: an important DNA repair enzyme.
R Glaser, BE Thorn, KL Tarr, JK Kiecolt-Glaser… - Health …, 1985 - psycnet.apa.org
R Glaser, BE Thorn, KL Tarr, JK Kiecolt-Glaser, SM D'Ambrosio
Health Psychology, 1985•psycnet.apa.orgExplored the relationship between stress and tumor development in 44 female Sprague-
Dawley rats given the carcinogen dimethylnitrosamine. Half were randomly assigned to a
rotational stress condition. Results indicate that the levels of methyltransferase, a DNA repair
enzyme induced in response to carcinogen damage, were significantly lower in spleens
from the stressed Ss, suggesting that stress may impair DNA repair. While it is not clear that
stressors such as periodic rotation parallel the physiological effects of psychological or …
Dawley rats given the carcinogen dimethylnitrosamine. Half were randomly assigned to a
rotational stress condition. Results indicate that the levels of methyltransferase, a DNA repair
enzyme induced in response to carcinogen damage, were significantly lower in spleens
from the stressed Ss, suggesting that stress may impair DNA repair. While it is not clear that
stressors such as periodic rotation parallel the physiological effects of psychological or …
Abstract
Explored the relationship between stress and tumor development in 44 female Sprague-Dawley rats given the carcinogen dimethylnitrosamine. Half were randomly assigned to a rotational stress condition. Results indicate that the levels of methyltransferase, a DNA repair enzyme induced in response to carcinogen damage, were significantly lower in spleens from the stressed Ss, suggesting that stress may impair DNA repair. While it is not clear that stressors such as periodic rotation parallel the physiological effects of psychological or social stress in humans, there are epidemiological data that link distress and cancer risk in humans.(26 ref)(PsycINFO Database Record (c) 2016 APA, all rights reserved)
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