Novel signaling pathway through the β-adrenergic receptor
YC Ma, XY Huang - Trends in Cardiovascular Medicine, 2002 - Elsevier
β-Adrenergic receptors transduce signals through the heterotrimeric G protein Gαs to
regulate cardiac function. Recently, it has been discovered that Gαs could directly stimulate
the Src family tyrosine kinase activity. This novel signaling pathway provides insights into the
cAMP–PKA-independent signaling mechanisms used by β-adrenergic receptors to regulate
apoptosis, receptor desensitization, and other physiological functions.
regulate cardiac function. Recently, it has been discovered that Gαs could directly stimulate
the Src family tyrosine kinase activity. This novel signaling pathway provides insights into the
cAMP–PKA-independent signaling mechanisms used by β-adrenergic receptors to regulate
apoptosis, receptor desensitization, and other physiological functions.