Administration of a monomeric CCL2 variant to EAE mice inhibits inflammatory cell recruitment and protects from demyelination and axonal loss
E Brini, F Ruffini, A Bergami, E Brambilla, G Dati… - Journal of …, 2009 - Elsevier
Based on gene expression data, we tested the P8A-CCL2 variant of the chemokine CCL2,
able to interfere with the chemotactic properties of the parental molecule, in relapsing–
remitting (RR)-EAE SJL. Only preventive treatment significantly delayed disease onset in a
dose dependent manner. P8A-CCL2 administration, however, decreased demyelination,
axonal loss and number of CNS infiltrating T cells and macrophages. Immunological
analysis revealed that P8A-CCL2 does not act on Ag-specific T cell proliferation and does …
able to interfere with the chemotactic properties of the parental molecule, in relapsing–
remitting (RR)-EAE SJL. Only preventive treatment significantly delayed disease onset in a
dose dependent manner. P8A-CCL2 administration, however, decreased demyelination,
axonal loss and number of CNS infiltrating T cells and macrophages. Immunological
analysis revealed that P8A-CCL2 does not act on Ag-specific T cell proliferation and does …