Oncolytic viruses are tumour selective and able to lyse cancer cells after infection. Reovirus
is an example of a wild-type oncolytic virus and is currently being investigated as a potential
novel therapy for cancer. This overview gives a brief description of what is known about
reovirus biology and summarises the preclinical data related to its oncolytic ability. The
completed and ongoing clinical trials involving reovirus, both as a single agent and in
combination with chemotherapy and radiotherapy, will be reviewed and their results …