[HTML][HTML] A Kaposi's sarcoma-associated herpesvirus-encoded cytokine homolog (vIL-6) activates signaling through the shared gp130 receptor subunit
The present studies analyzed the biologic activity of a gene product (vIL-6) encoded by the
recently discovered Kaposi's sarcoma-associated herpesvirus (KSHV) bearing 24.8% amino
acid identity with human interleukin-6 (huIL-6). Based on this similarity, we hypothesized that
this viral homolog might trigger the JAK/STAT pathway, which typically is engaged by IL-6
and other cytokines. Activation of receptor-associated Janus tyrosine kinases (JAKs) results
in the subsequent phosphorylation of signal transducers and activators of transcription …
recently discovered Kaposi's sarcoma-associated herpesvirus (KSHV) bearing 24.8% amino
acid identity with human interleukin-6 (huIL-6). Based on this similarity, we hypothesized that
this viral homolog might trigger the JAK/STAT pathway, which typically is engaged by IL-6
and other cytokines. Activation of receptor-associated Janus tyrosine kinases (JAKs) results
in the subsequent phosphorylation of signal transducers and activators of transcription …
