[HTML][HTML] Hurp deficiency in mice leads to female infertility caused by an implantation defect
CY Tsai, CK Chou, CW Yang, YC Lai, CC Liang… - Journal of Biological …, 2008 - ASBMB
First revealed in cancer studies, HURP (hepatoma up-regulated protein) is a cell cycle-
associated gene with elevated expression in the G 2/M phase. Cell culture studies have
revealed that HURP is an essential factor required for spindle formation and chromosome
congression during mitosis. However, the function of HURP in an in vivo context has not
been explored. We generated a Hurp knock-out (Hurp–/–) mouse to investigate the role of
HURP in development under normal physiological conditions. Hurp–/–mice develop …
associated gene with elevated expression in the G 2/M phase. Cell culture studies have
revealed that HURP is an essential factor required for spindle formation and chromosome
congression during mitosis. However, the function of HURP in an in vivo context has not
been explored. We generated a Hurp knock-out (Hurp–/–) mouse to investigate the role of
HURP in development under normal physiological conditions. Hurp–/–mice develop …