[HTML][HTML] Effects of follicle-stimulating hormone (FSH) and human chorionic gonadotropin in individuals with an inactivating mutation of the FSH receptor

TE Vaskivuo, K Aittomäki, M Anttonen, A Ruokonen… - Fertility and sterility, 2002 - Elsevier
Objective: To study the gonadal steroid responses to FSH and hCG in individuals with the
inherited Finnish-type inactivating Ala189Val mutation of the FSH receptor gene. Design:
Prospective clinical and descriptive study. Setting: University hospital. Patient (s): Two
women and one man homozygous for the Ala189Val mutation of the FSH receptor gene,
and ovarian biopsies from four affected and four healthy women, and four normal fetuses.
Intervention (s): Individuals were treated with increasing doses of recombinant FSH (300 …